dr. robert casey yale child study center

Dylan Gee, is seeking a full-time research assistant to begin in summer or fall 2018 (start date flexible) to coordinate a new NIMH-funded study of the neural mechanisms underlying a novel psychosocial treatment for pediatric anxiety disorders. The Clinical Affective Neuroscience & Development Lab at Yale, directed by Dr. In the discussion we highlight important details on interpretations and implications of this study. Much work remains to be done, and we hope this study helps to provide insight into the nature of brain development among youth with PTSD! Findings suggested that the volumetric differences observed in pediatric PTSD may be distinct from pediatric depression and partially overlapping with pediatric anxiety.įuture research will benefit from examining co-occurring clinical presentations that are common among youth exposed to trauma, dimensional approaches that may better capture heterogeneous symptoms, and study designs that can clarify developmental effects of trauma and PTSD. Thus, volumetric differences in pediatric PTSD are unlikely to be explained solely by trauma exposure. Whereas pediatric PTSD was associated with smaller hippocampal and amygdala volumes, trauma exposure without PTSD was associated with larger volumes. Youth with PTSD differed from youth who were exposed to trauma but did not develop PTSD. Sex was a moderator for hippocampal and amygdala volume, with studies with higher percentages of females more likely to observe smaller volume in pediatric PTSD. Age was a moderator for hippocampal volume, with studies of older individuals more likely to observe smaller volume in pediatric PTSD. This hippocampal alteration was similar to that observed in adults with PTSD. In this meta-analysis we found that pediatric PTSD was associated with smaller gray matter volume in various regions including the hippocampus. In this work we aimed to address the following questions: What differences in brain volume are associated with pediatric PTSD? Do findings in pediatric PTSD differ from those in adults with PTSD? To what extent do these differences relate to PTSD vs trauma exposure itself? To what extent are these differences specific to PTSD vs anxiety and depression, which are often co-occurring in youth with PTSD?įindings from individual studies of youth with PTSD have been varied, and some have suggested that there are no differences in hippocampal or amygdala volumes between youth w/ and w/o PTSD. You can find the study here and a summary below: Andrea Danese, Konstantinos Bromis, and Matthew Kempton. This research was led by MD/PhD student Sahana Kribakaran and conducted in collaboration with Drs. The CANDLab has published a new study on brain development in youth with post-traumatic stress disorder (PTSD).

These findings have broad implications for optimizing interventions for anxiety disorders and for investigating novel approaches to fear reduction. Parallel findings in humans (led by co-first author Paola Odriozola) demonstrated the involvement of hippocampal-dorsal ACC (but not hippocampal-ventromedial PFC or hippocampal-amygdala). Importantly, this pathway differed from the ventromedial PFC-amygdala pathway implicated in fear extinction. Heidi Meyer), fiber photometry recordings demonstrated that ventral hippocampal neurons projecting to prelimbic cortex (but not infralimbic cortex or the basolateral amygdala) were involved in conditioned inhibition via learned safety. In this new research we found that learned safety signals reduced threat responding across mice and humans. Francis Lee's lab at Weill Cornell Medicine was recently published in PNAS. It does not store any personal data.A cross-species collaborative study between the CANDLab and Dr. The cookie is set by the GDPR Cookie Consent plugin and is used to store whether or not user has consented to the use of cookies. The cookie is used to store the user consent for the cookies in the category 'Performance'. This cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category 'Other. The cookies is used to store the user consent for the cookies in the category 'Necessary'.

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Dr. robert casey yale child study center